Post by sagobob on Jun 29, 2020 13:28:19 GMT -8
In today's WaPo Coronavirus Newsletter there's an article on a particularly contagious mutant, known simply as "G".
From the article:
"When the first coronavirus cases in Chicago appeared in January, they bore the same genetic signatures as a germ that emerged in China weeks before.
But as Egon Ozer, an infectious-disease specialist at the Northwestern University Feinberg School of Medicine, examined the genetic structure of virus samples from local patients, he noticed something different.
A change in the virus was appearing again and again. This mutation, associated with outbreaks in Europe and New York, eventually took over the city. By May, it was found in 95 percent of all the genomes Ozer sequenced.
At a glance, the mutation seemed trivial. About 1,300 amino acids serve as building blocks for a protein on the surface of the virus. In the mutant virus, the genetic instructions for just one of those amino acids — number 614 — switched in the new variant from a 'D' (shorthand for aspartic acid) to a 'G' (short for glycine).
But the location was significant, because the switch occurred in the part of the genome that codes for the all-important 'spike protein' — the protruding structure that gives the coronavirus its crownlike profile and allows it to enter human cells the way a burglar picks a lock. And its ubiquity is undeniable. Of the approximately 50,000 genomes of the new virus that researchers worldwide have uploaded to a shared database, about 70 percent carry the mutation, officially designated D614G but known more familiarly to scientists as 'G'."
"G" has become the dominant variant worldwide and while it doesn't appear to make those infected sicker, it is said to be more contagious. The findings so far on this variant are preliminary and subject to peer review. Nonetheless they're troubling. Herd immunity could come quicker than one imagines, but at a price of more lost human lives.
From the article:
"When the first coronavirus cases in Chicago appeared in January, they bore the same genetic signatures as a germ that emerged in China weeks before.
But as Egon Ozer, an infectious-disease specialist at the Northwestern University Feinberg School of Medicine, examined the genetic structure of virus samples from local patients, he noticed something different.
A change in the virus was appearing again and again. This mutation, associated with outbreaks in Europe and New York, eventually took over the city. By May, it was found in 95 percent of all the genomes Ozer sequenced.
At a glance, the mutation seemed trivial. About 1,300 amino acids serve as building blocks for a protein on the surface of the virus. In the mutant virus, the genetic instructions for just one of those amino acids — number 614 — switched in the new variant from a 'D' (shorthand for aspartic acid) to a 'G' (short for glycine).
But the location was significant, because the switch occurred in the part of the genome that codes for the all-important 'spike protein' — the protruding structure that gives the coronavirus its crownlike profile and allows it to enter human cells the way a burglar picks a lock. And its ubiquity is undeniable. Of the approximately 50,000 genomes of the new virus that researchers worldwide have uploaded to a shared database, about 70 percent carry the mutation, officially designated D614G but known more familiarly to scientists as 'G'."
"G" has become the dominant variant worldwide and while it doesn't appear to make those infected sicker, it is said to be more contagious. The findings so far on this variant are preliminary and subject to peer review. Nonetheless they're troubling. Herd immunity could come quicker than one imagines, but at a price of more lost human lives.